1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

Base Information

Chemical Name:1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one
CAS No.:1430092-02-6
Molecular Formula:C₁₉H₃₂N₂O₂Si
Molecular Weight:348.561
Hs Code.:

Synonyms:1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

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Chemical Property of 1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

Chemical Property:

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Technology Process of 1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

There total 6 articles about 1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 67-56-1
methanol

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1430092-01-5
1-[2-(2-{[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

: 1430092-02-6
1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

Guidance literature:: With potassium carbonate; In water; at -10 - 0 ℃; for 2h;

Reference yield:

: 5339-85-5
2-aminophenethyl alcohol

: 1430092-02-6
1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 2 h / 85 °C / Inert atmosphere

5.1: potassium carbonate / water / 2 h / -10 - 0 °C

With dmap; potassium tert-butylate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 1430092-02-6
1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 2 h / 85 °C / Inert atmosphere

5.1: potassium carbonate / water / 2 h / -10 - 0 °C

With dmap; potassium tert-butylate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;