3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester

Base Information

• Chemical Name: 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester
• CAS No.: 229487-03-0
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.297
• Mol file: 229487-03-0.mol

Synonyms:3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester

Chemical Property of 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester

There total 4 articles about 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-benzyloxycarbonylamino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester (229487-00-7) → 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester (229487-03-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1055/s-1999-3094

Reference yield:

N-methyl-2-hydroxybenzylamine (60399-02-2) → 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester (229487-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / HOBT, DCC

2: 91 percent / H₂ / 10 percent Pd/C / ethanol

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;

DOI:10.1055/s-1999-3094

Reference yield:

N-salicylidene methylamine (107910-69-0) → 3-amino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester (229487-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / ethanol

2: 81 percent / HOBT, DCC

3: 91 percent / H₂ / 10 percent Pd/C / ethanol

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;

DOI:10.1055/s-1999-3094

upstream raw materials:

3-benzyloxycarbonylamino-N-(2-hydroxy-benzyl)-N-methyl-succinamic acid methyl ester

N-salicylidene methylamine

N-methyl-2-hydroxybenzylamine

salicylaldehyde