2-[(Methylamino)methyl]phenol

Base Information

• Chemical Name: 2-[(Methylamino)methyl]phenol
• CAS No.: 60399-02-2
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• European Community (EC) Number: 672-632-0
• DSSTox Substance ID: DTXSID60975801
• Nikkaji Number: J253.923C
• Wikidata: Q72485121
• Mol file: 60399-02-2.mol

Synonyms:2-[(methylamino)methyl]phenol;60399-02-2;2-((methylamino)methyl)phenol;2-(methylaminomethyl)phenol;2-Hydroxy-n-methylbenzylamine HCl;N-methyl-2-HOBA (hydrochloride);Phenol, 2-[(methylamino)methyl]-;2-hydroxy-N-methylbenzylamine;QSPL 312;SCHEMBL1488766;DTXSID60975801;PVFSNBPKQDSTPP-UHFFFAOYSA-N;AKOS000127852;Benzenemethanamine,2-hydroxy-N-methyl-;KF-0722;Benzenemethanamine, 2-hydroxy-N-methyl-;D91425;EN300-144484;F2169-1257

Chemical Property of 2-[(Methylamino)methyl]phenol

Chemical Property:

• Melting Point: 148°C
• PSA: 32.26000
• LogP: 2.30450
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-N-methylbenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=CC=CC=C1O

Technology Process of 2-[(Methylamino)methyl]phenol

There total 17 articles about 2-[(Methylamino)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C16H23BNO(1-)*H(1+) → N-methyl-2-hydroxybenzylamine (60399-02-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 48h;

DOI:10.1021/ol048554k

Reference yield: 90.0%

2-(methyliminomethyl)phenol (3117-65-5) → N-methyl-2-hydroxybenzylamine (60399-02-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h;

Reference yield: 90.0%

salicylaldehyde (90-02-8) + methylamine (74-89-5) → N-methyl-2-hydroxybenzylamine (60399-02-2)

Guidance literature:

salicylaldehyde; methylamine; In ethanol; at 60 ℃; for 4h;

With sodium tetrahydroborate; In ethanol; Further stages.;

DOI:10.1080/00397910802138629

upstream raw materials:

N-(2-Hydroxy-benzyl)-N-methyl-formamid

2-(methyliminomethyl)phenol

N-salicylidene methylamine

2-Hydroxybenzylamine

Downstream raw materials:

methylamine

N-(2-hydroxybenzyl)-N-methylbenzamide

3-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

3-Chlorophenyl N-(2-hydroxybenzyl)-N-methylcarbamate