3'-(Trifluoromethyl)-biphenyl-4-methanamine

Base Information

Chemical Name:3'-(Trifluoromethyl)-biphenyl-4-methanamine
CAS No.:472964-21-9
Molecular Formula:C₁₄H₁₂F₃N
Molecular Weight:251.251
Hs Code.:
DSSTox Substance ID:DTXSID401231303
Mol file:472964-21-9.mol

Synonyms:472964-21-9;3'-(Trifluoromethyl)-biphenyl-4-methanamine;AKOS BAR-2014;SCHEMBL16894228;DTXSID401231303;AKOS002678597;NCGC00373783-01;C78245;C-(3'-trifluoromethyl-biphenyl-4-yl)-methylamine;3'-(Trifluoromethyl)[1,1'-biphenyl]-4-methanamine

Suppliers and Price of 3'-(Trifluoromethyl)-biphenyl-4-methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(4-[3-(TRIFLUOROMETHYL)PHENYL]PHENYL)METHANAMINE 95.00%
5MG
$ 500.12

Acrotein
3'-(Trifluoromethyl)-biphenyl-4-methanamine 97%
5g
$ 825.00

Total 2 raw suppliers

Chemical Property of 3'-(Trifluoromethyl)-biphenyl-4-methanamine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:251.09218387
Heavy Atom Count:18
Complexity:256

Purity/Quality:

95%-98% ^*data from raw suppliers

(4-[3-(TRIFLUOROMETHYL)PHENYL]PHENYL)METHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(C=C2)CN

Technology Process of 3'-(Trifluoromethyl)-biphenyl-4-methanamine

There total 5 articles about 3'-(Trifluoromethyl)-biphenyl-4-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 4-(aminomethyl)phenylboronic acid hydrochloride

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 472964-21-9
C-(3'-trifluoromethylbiphenyl-4-yl)methylamine

Guidance literature:: With dipotassium hydrogenphosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 120 ℃; for 4h; Inert atmosphere; Sealed tube;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 472964-21-9
C-(3'-trifluoromethylbiphenyl-4-yl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere; Enzymatic reaction

1.3: 1 h / 20 °C

2.1: sodium hydroxide / water / pH 10

With potassium carbonate; sodium hydroxide; In water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/jm500707r

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 472964-21-9
C-(3'-trifluoromethylbiphenyl-4-yl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere; Enzymatic reaction

1.3: 1 h / 20 °C

2.1: sodium hydroxide / water / pH 10

With potassium carbonate; sodium hydroxide; In water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/jm500707r