(Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid

Base Information

• Chemical Name: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid
• CAS No.: 350986-48-0
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Mol file: 350986-48-0.mol

Synonyms:(Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid

Chemical Property of (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid

There total 1 articles about (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + ethyl 2-cyanoacetate (105-56-6) → (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid (350986-48-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; at 85 ℃; for 1h;

Reference yield: 96.0%

(Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid (350986-48-0) → 2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester (29958-02-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1081/SCC-120025194

Reference yield:

1,2-diamino-benzene (95-54-5) + (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid (350986-48-0) → 2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole (175714-45-1) + 2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester (29958-02-9) + ethyl 2-cyanoacetate (105-56-6)

Guidance literature:

at 140 ℃; for 0.75h;

DOI:10.1055/s-2007-991087

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

ethyl 2-cyanoacetate

Downstream raw materials:

2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester

2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole

ethyl 2-cyanoacetate

5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine