3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Base Information

Chemical Name:3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
CAS No.:1567370-93-7
Molecular Formula:C₂₅H₂₁ClN₄O
Molecular Weight:428.921
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Chemical Property of 3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Technology Process of 3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

There total 6 articles about 3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1567373-41-4
3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 1567370-93-7
3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: With triethylamine; In dichloromethane; for 1h;

Reference yield:

: 1567373-39-0
tert-butyl (3-(4-chlorophenyl)prop-2-yn-1-yl)(2-(2-(2-ethylphenyl)hydrazinyl)-2-oxoethyl)carbamate

: 1567370-93-7
3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h

2: triethylamine / toluene / 100 °C

3: trifluoroacetic acid / dichloromethane / 2 h

4: triethylamine / dichloromethane / 1 h

With tetrachloromethane; triethylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 158979-29-4
2-((tert-butoxycarbonyl)(prop-2-yn-1-yl)-amino)acetic acid

: 1567370-93-7
3-(4-chlorophenyl)-2-(2-ethylphenyl)-5-(pyridin-3-ylcarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.25 h

2.2: 1 h

3.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h

4.1: triethylamine / toluene / 100 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h

6.1: triethylamine / dichloromethane / 1 h

With tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;