2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

Base Information

Chemical Name:2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid
CAS No.:1567373-38-9
Molecular Formula:C₁₆H₁₈ClNO₄
Molecular Weight:323.776
Hs Code.:

Synonyms:2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

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Chemical Property of 2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

Chemical Property:

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Technology Process of 2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

There total 2 articles about 2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 158979-29-4
2-((tert-butoxycarbonyl)(prop-2-yn-1-yl)-amino)acetic acid

: 1567373-38-9
2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 4530-20-5
BOC-glycine

: 1567373-38-9
2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1567373-38-9
2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid

: 1586755-72-7
tert-butyl (2-chloro-2-(2-(2-ethylphenyl)hydrazono)ethyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.25 h

1.2: 1 h

2.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h

With tetrachloromethane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In acetonitrile;