1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

Base Information

Chemical Name:1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane
CAS No.:554430-90-9
Molecular Formula:C₄₂H₅₉NO₅Si₂
Molecular Weight:714.105
Hs Code.:

Synonyms:1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

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Chemical Property of 1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

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Technology Process of 1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

There total 6 articles about 1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554430-13-6
2-[4-{[4-(2-azepan-1-yl-ethoxy)-phenyl]hydroxymethyl}-7-(tert-butyl-dimethyl-silyloxy)-2H-chromen-3-yl]-5-(tert-butyl-dimethyl-silyloxy)-phenol

: 554430-90-9
1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

Guidance literature:: With 4 A molecular sieve; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/jm060353u

Reference yield:

: 554430-87-4
2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one

: 554430-90-9
1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminum hydride / toluene / 5 h / -78 °C

2.1: isopropylmagnesium bromide / tetrahydrofuran; diethyl ether / 7 h / -18 °C

2.2: tetrahydrofuran; diethyl ether / 11 h / -18 - 20 °C

3.1: PPh₃; diethyl diazodicarboxylate; molecular sieves 4 Angstroem / tetrahydrofuran / 18 h / 20 °C

With 4 A molecular sieve; isopropylmagnesium bromide; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm060353u

Reference yield:

: 553681-47-3
2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol

: 554430-90-9
1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-azepane

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran; diethyl ether / 7 h / -18 °C

1.2: tetrahydrofuran; diethyl ether / 11 h / -18 - 20 °C

2.1: PPh₃; diethyl diazodicarboxylate; molecular sieves 4 Angstroem / tetrahydrofuran / 18 h / 20 °C

With 4 A molecular sieve; isopropylmagnesium bromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 2.1: Mitsunobu reaction;
DOI:10.1021/jm060353u