1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

Base Information Edit

Chemical Name:1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
CAS No.:906329-46-2
Molecular Formula:C₁₉H₂₆FNO₄
Molecular Weight:351.418
Hs Code.:
Mol file:906329-46-2.mol

Synonyms:1-tert-butyl 4-methyl 4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate

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Chemical Property of 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER Edit

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Technology Process of 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

There total 3 articles about 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 459-46-1
4-Fluorobenzyl bromide

: 906329-46-2
1-tert-butyl 4-methyl 4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate

Guidance literature:: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 30 ℃; for 0.833333h;

4-Fluorobenzyl bromide; In tetrahydrofuran; n-heptane; ethylbenzene; at -20 - 0 ℃; for 2.5h;

With ammonium chloride; In tetrahydrofuran; n-heptane; ethylbenzene; water;

Reference yield: 74.0%

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 459-46-1
4-Fluorobenzyl bromide

: 906329-46-2
1-tert-butyl 4-methyl 4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate

Guidance literature:: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1h;

4-Fluorobenzyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;