1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE

Base Information

Chemical Name:1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE
CAS No.:917755-78-3
Molecular Formula:C18H26FNO3
Molecular Weight:323.408
Hs Code.:
Mol file:917755-78-3.mol

Synonyms:1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE

Suppliers and Price of 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
tert-Butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)-1-piperidinecarboxylate AldrichCPR
5mg
$ 322.00

American Custom Chemicals Corporation
1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)PIPERIDINE 95.00%
5MG
$ 505.60

Total 1 raw suppliers

Chemical Property of 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE

Chemical Property:

PSA：49.77000
LogP:3.31570

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)-1-piperidinecarboxylate AldrichCPR ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE

There total 4 articles about 1-BOC-4-[(4-FLUOROPHENYL)METHYL]-4-(HYDROXYMETHYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 906329-46-2
1-tert-butyl 4-methyl 4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate

: 917755-78-3
tert-butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 917755-77-2
4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 917755-78-3
tert-butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: 4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 10 ℃;

With water; sodium hydroxide; In diethyl ether;

Reference yield:

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 917755-78-3
tert-butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran; hexane

2: lithium aluminium tetrahydride / tetrahydrofuran; water

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; hexane; water;