3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole

Base Information

• Chemical Name: 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole
• CAS No.: 1562569-89-4
• Molecular Formula: C₁₆H₁₄N₄O₃S
• Molecular Weight: 342.378
• Mol file: 1562569-89-4.mol

Synonyms:3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole

Chemical Property of 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole

There total 1 articles about 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxybenzenesulfonyl azide (4547-64-2) + 2-methylaminophenylacetylene (923270-57-9) → 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole (1562569-89-4)

Guidance literature:

With triethylamine; copper(l) chloride; In acetonitrile; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol5002347

Reference yield: 90.0%

3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole (1562569-89-4) + 1-indene (95-13-6) → 4-methoxy-N-(1'-methyl-1a,6a-dihydro-6H-spiro[(trans)-cyclopropa[a]indene-1,3'-indolin]-2'-ylidene)benzenesulfonamide

Guidance literature:

With rhodium (II) octanoate dimer; In 1,2-dichloro-ethane; for 6h; diastereoselective reaction; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/ol5002347

Reference yield: 77.0%

4-Methoxystyrene (637-69-4,24936-44-5) + 3-((4-methoxyphenyl)sulfonyl)-4-methyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole (1562569-89-4) → 2-(4-methoxyphenyl)-1-((4-methoxyphenyl)sulfonyl)-8-methyl-1,2,3,8-tetrahydropyrrolo[2,3-b]indole (1562571-30-5)

Guidance literature:

With rhodium (II) octanoate dimer; In 1,2-dichloro-ethane; for 6h; regioselective reaction; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/ol5002347

upstream raw materials:

4-methoxybenzenesulfonyl azide

2-methylaminophenylacetylene

Downstream raw materials:

2-(4-methoxyphenyl)-1-((4-methoxyphenyl)sulfonyl)-8-methyl-1,2,3,8-tetrahydropyrrolo[2,3-b]indole