methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Base Information

Chemical Name:methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate
CAS No.:1609543-79-4
Molecular Formula:C₂₅H₂₁ClF₃N₃O₃
Molecular Weight:503.908
Hs Code.:

Synonyms:methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

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Chemical Property of methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

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Technology Process of methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

There total 10 articles about methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1609543-55-6
methyl 2-(1-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1609543-56-7
6-bromo-N-(3-chlorophenyl)pyridazin-3-amine

: 1609543-79-4
methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 1609543-54-5
methyl 2-(1-oxo-2-(2,2,2-trifluoroethyl)-6-(trifluoromethylsulfonyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1609543-79-4
methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 3 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; In 1,4-dioxane; water;

Reference yield:

: 50558-96-8
6-methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid, ethyl ester

: 1609543-79-4
methyl 2-(6-(6-((3-chlorophenyl)amino)pyridazin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / Cooling with ice

1.2: 3 h / 20 °C

2.1: hydrogen bromide / water / Reflux

3.1: 3 h / 80 °C

4.1: pyridine / dichloromethane / 3 h / 20 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 3 h / Inert atmosphere; Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; potassium acetate; sodium hydride; caesium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;