cyclo(glycine-(1-amino-1-cyclopentane)carbonyl)

Base Information

• Chemical Name: cyclo(glycine-(1-amino-1-cyclopentane)carbonyl)
• CAS No.: 90392-32-8
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.195
• Mol file: 90392-32-8.mol

Synonyms:cyclo(glycine-(1-amino-1-cyclopentane)carbonyl)

Chemical Property of cyclo(glycine-(1-amino-1-cyclopentane)carbonyl)

Chemical Property:

• Vapor Pressure: 4.42E-11mmHg at 25°C
• Melting Point: 275-280 °C (decomp)(Solv: water (7732-18-5))
• Boiling Point: 524.2°Cat760mmHg
• PKA: 13.03±0.20(Predicted)
• Flash Point: 253.6°C
• PSA: 65.18000
• Density: 1.25g/cm³
• LogP: 0.09700

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclo(glycine-(1-amino-1-cyclopentane)carbonyl)

There total 4 articles about cyclo(glycine-(1-amino-1-cyclopentane)carbonyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

1-N-carbobenzyloxyglycylamino-1-ethoxycarbonylcyclopentane (93948-00-6) → 6,9-diaza-7,10-dioxospiro<4,5>decane (90392-32-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 3040 Torr;

DOI:10.1139/v92-171

Reference yield:

1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride (22649-37-2) → 6,9-diaza-7,10-dioxospiro<4,5>decane (90392-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

2: 71.4 percent / H₂ / 10percent Pd/C / ethanol / 18 h / 3040 Torr

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1139/v92-171

Reference yield:

1-amino-1-cyclopentanecarboxylic acid (52-52-8) → 6,9-diaza-7,10-dioxospiro<4,5>decane (90392-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / thionyl chloride / 4 h / Heating

2: 88 percent / NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

3: 71.4 percent / H₂ / 10percent Pd/C / ethanol / 18 h / 3040 Torr

With thionyl chloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1139/v92-171

upstream raw materials:

1-N-carbobenzyloxyglycylamino-1-ethoxycarbonylcyclopentane

1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride

1-amino-1-cyclopentanecarboxylic acid

Downstream raw materials:

ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate

ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylate

1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

Refernces