ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate

Base Information

• Chemical Name: ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate
• CAS No.: 811437-02-2
• Molecular Formula: C₂₀H₁₆Cl₂N₂O₃
• Molecular Weight: 403.265
• Mol file: 811437-02-2.mol

Synonyms:ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate

Chemical Property of ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate

There total 1 articles about ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5,6-bis(4-chlorophenyl)-3-(ethoxycarbonyl)pyrazine-2-carboxylic acid → ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate (811437-02-2)

Guidance literature:

5,6-bis(4-chlorophenyl)-3-(ethoxycarbonyl)pyrazine-2-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -20 - 0 ℃; for 2.08333h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at -20 ℃; for 1.08333h;

With hydrogenchloride; In tetrahydrofuran; water; at -20 - -10 ℃; for 1h;

Reference yield: 97.0%

ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate (811437-02-2) + methanesulfonyl chloride (124-63-0) → ethyl 5,6-bis(4-chlorophenyl)-3-{[(methylsulfonyl)oxy]methyl}pyrazine-2-carboxylate (811441-13-1)

Guidance literature:

ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate; With triethylamine; In dichloromethane; at 20 ℃;

methanesulfonyl chloride; In dichloromethane; at 0 ℃; for 0.666667h;

Reference yield: 79.0%

ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate (811437-02-2) → ethyl 5,6-bis(4-chlorophenyl)-3-formylpyrazine-2-carboxylate (811441-09-5)

Guidance literature:

ethyl 5,6-bis(4-chlorophenyl)-3-(hydroxymethyl)pyrazine-2-carboxylate; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water;

Downstream raw materials:

5,6-bis(4-chlorophenyl)-3-(methoxymethyl)pyrazine-2-carboxylic acid

ethyl 5,6-bis(4-chlorophenyl)-3-(2H-tetrazol-2-ylmethyl)pyrazine-2-carboxylate

ethyl 3-(bromomethyl)-5,6-bis(4-chlorophenyl)pyrazine-2-carboxylate

ethyl 5,6-bis(4-chlorophenyl)-3-formylpyrazine-2-carboxylate