1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

Base Information

Chemical Name:1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone
CAS No.:679405-25-5
Molecular Formula:C₁₇H₁₃ClF₂N₄O₂
Molecular Weight:378.766
Hs Code.:

Synonyms:1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

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Chemical Property of 1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

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Technology Process of 1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

There total 10 articles about 1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372118-01-9
4,6-dichloro-pyridazine-3-carboxylic acid methyl ester

: 679405-25-5
1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; methanol / 0 - 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 3 h / 0 °C

3.1: thionyl chloride / dichloromethane / 4 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 110 °C

5.2: 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 679405-22-2
6-Chloro-3-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-4-methoxy-pyridazine

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: 679405-25-5
1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

Guidance literature:: 6-Chloro-3-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-4-methoxy-pyridazine; tributyl(1-ethoxyvinyl)stannane; With bis-triphenylphosphine-palladium(II) chloride; In toluene; at 110 ℃; for 24h;

With hydrogenchloride; In water; toluene; at 20 ℃; for 2h;

Reference yield:

: 372118-00-8
4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester

: 679405-25-5
1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 4 h / 95 °C

2.1: tetrahydrofuran; methanol / 0 - 20 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 3 h / 0 °C

4.1: thionyl chloride / dichloromethane / 4 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

6.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 110 °C

6.2: 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sodium hydride; diisobutylaluminium hydride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;