(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate
CAS No.:1062642-68-5
Molecular Formula:C₃₂H₃₀F₅N₃O₅
Molecular Weight:631.599
Hs Code.:

(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Synonyms:(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of (R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

There total 6 articles about (R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (R)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-hydroxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

: 24424-99-5
di-tert-butyl dicarbonate

: 1062642-68-5
(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; for 5h;

Reference yield:

: 830346-47-9
1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione

: 1062642-68-5
(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; bromine / 14 h

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 14 h

3: potassium carbonate; XPhos; palladium diacetate / toluene / 16 h / 110 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 12.5 h / -78 - 25 °C / Inert atmosphere

5: triethylamine / dichloromethane / 5 h

With bromine; palladium diacetate; boron tribromide; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; XPhos; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 239087-06-0
(2-fluoro-6-(trifluoromethyl) phenyl)methanamine

: 1062642-68-5
(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 12 h / 100 °C

2: sodium iodide; chloro-trimethyl-silane / acetonitrile / 16 h / 0 - 25 °C / Inert atmosphere

3: acetic acid; bromine / 14 h

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 14 h

5: potassium carbonate; XPhos; palladium diacetate / toluene / 16 h / 110 °C / Inert atmosphere

6: boron tribromide / dichloromethane / 12.5 h / -78 - 25 °C / Inert atmosphere

7: triethylamine / dichloromethane / 5 h

With hydrogenchloride; chloro-trimethyl-silane; bromine; palladium diacetate; boron tribromide; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; sodium iodide; diethylazodicarboxylate; XPhos; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;