4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate
CAS No.:1362688-92-3
Molecular Formula:C₃₅H₄₅N₆O₉P
Molecular Weight:724.751
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

There total 4 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₅₃N₆O₁₁P

: 1362688-92-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: C₄₀H₅₃N₆O₁₁P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1362688-92-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 22410-97-5
(RS)-2-(4-benzoylphenyl)propanoic acid

: 1362688-92-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013