phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

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Chemical Name:phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate
CAS No.:1301767-97-4
Molecular Formula:C₂₇H₃₀N₂O₅S
Molecular Weight:494.612
Hs Code.:

Synonyms:phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

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Chemical Property of phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

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Technology Process of phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

There total 5 articles about phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1301768-08-0
(4R)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyl]-4-methyl-2,3,4,5-tetrahydro-1H-1λ6,2-benzothiazepine-1,1-dione

: 1885-14-9
phenyl chloroformate

: 1301767-97-4
phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1301767-97-4
phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 8 - 10 h / 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile) / toluene / 60 - 70 °C

2.2: Inert atmosphere; Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 10 - 12 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 - 4 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With pyridine; 2,2'-azobis(isobutyronitrile); caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1301767-83-8
2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione

: 1301767-97-4
phenyl N-{(1R,2S)-1-benzyl-2-hydroxy-3-[(4R)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 - 4 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;