3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

Base Information

Chemical Name:3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline
CAS No.:849217-47-6
Molecular Formula:C₂₃H₂₆FN₃O₃
Molecular Weight:411.476
Hs Code.:

Synonyms:3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

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Chemical Property of 3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

Chemical Property:

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Technology Process of 3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

There total 15 articles about 3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinoline

: 849217-47-6
3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: With iron; In ethanol; water; Reflux;
DOI:10.1016/j.ejmech.2020.112174

Reference yield:

: 205448-29-9,849217-23-8
7-benzyloxy-4-hydroxy-6-methoxyquinoline

: 849217-47-6
3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 0.5 h / 20 °C

1.2: 2.17 h

2.1: hydrogen bromide; acetic acid / 3 - 4 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h

5.1: sodium tris(acetoxy)borohydride / water / 12 h

6.1: hydrogen / palladium 10% on activated carbon / ethanol; acetic acid / 22 h / 2068.65 Torr

With hydrogen bromide; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 479690-03-4
7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methyloxyquinoline

: 849217-47-6
3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen bromide; acetic acid / 3 - 4 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 1.5 h

4: sodium tris(acetoxy)borohydride / water / 12 h

5: hydrogen / palladium 10% on activated carbon / ethanol; acetic acid / 22 h / 2068.65 Torr

With hydrogen bromide; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;