1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone

Base Information

• Chemical Name: 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone
• CAS No.: 75665-73-5
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• Hs Code.: 2922509090
• Mol file: 75665-73-5.mol

Synonyms:1-[2-AMINO-5-METHOXY-4-(PHENYLMETHOXY)PHENYL]ETHANONE

Chemical Property of 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone

Chemical Property:

• Melting Point: 135-137℃
• Boiling Point: 450.4±40.0 °C(Predicted)
• PKA: 2.48±0.10(Predicted)
• PSA: 61.55000
• Density: 1.169
• LogP: 3.64020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%, ^*data from raw suppliers

1-(2-Amino-4-(benzyloxy)-5-methoxyphenyl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Amino-4-benzyloxy-5-methoxy-phenyl)-ethanone is a useful research chemical.

Technology Process of 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone

There total 7 articles about 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone (75665-88-2) → 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5)

Guidance literature:

With ammonium acetate; iron; In water; toluene; at 105 ℃;

Reference yield: 77.0%

benzyl bromide (100-39-0) + 1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5)

Guidance literature:

With sodium hydroxide; ammonium chloride; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; In ethanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield: 70.0%

4-benzyloxy-3-methoxyacetophenone (1835-11-6) + benzyl bromide (100-39-0) + 1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) + 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone (75665-88-2) → 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5)

Guidance literature:

With iron; potassium carbonate; In dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;

upstream raw materials:

4-benzyloxy-3-methoxyacetophenone

benzyl bromide

tin(IV) chloride

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

6-methoxy-7-benzyloxy-4(1H)-quinolinone

7-benzyloxy-4-hydroxy-6-methoxyquinoline

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline

Refernces

• 1、 -. "CARBAMATE AND UREA COMPOUNDS AS MULTIKINASE INHIBITORS". Paragraph 070. . Retrieved 2019/07/13.
• 2、 Yang, Hao,Murigi, Francis N.,Wang, Zhijian,Li, Junfeng,Jin, Hongjun,Tu, Zhude. "Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors". supporting information. p. 919 - 924. Retrieved 2015/02/19.