methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

Base Information

Chemical Name:methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate
CAS No.:913078-91-8
Molecular Formula:C₂₇H₂₆F₃NO₆S
Molecular Weight:549.568
Hs Code.:

Synonyms:methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

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Chemical Property of methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

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Technology Process of methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

There total 12 articles about methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-3-Chloro-3-(4-{2-[isobutyl-(5-methyl-furan-2-sulfonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-phenyl)-acrylic acid methyl ester

: 913078-91-8
methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

Guidance literature:: In 1,2-dichloro-benzene; at 200 ℃; for 3.5h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 534-22-5
2-methylfuran

: 913078-91-8
methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / acetonitrile / 23 h / 40 °C

2: 41 percent / oxalyl chloride / 1,2-dimethoxy-ethane; dimethylformamide / 3 h / 20 °C

3: 80 percent / pyridine / CH₂Cl₂ / 9 h

4: 94 percent / potassium carbonate / dimethylformamide / 80 °C

5: 88 percent / sodium hydroxide / dioxane; methanol; H₂O

6: thionyl chloride / ethyl acetate / 1.5 h / 80 °C

7: triethylamine / toluene / 3 h / 125 °C

8: 170 mg / 1,2-dichloro-benzene / 3.5 h / 200 °C

With pyridine; sodium hydroxide; thionyl chloride; oxalyl dichloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene; toluene; acetonitrile; 7: Wittig reaction;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 907587-49-9
methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 913078-91-8
methyl 3-(4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)prop-2-ynoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / pyridine / CH₂Cl₂ / 9 h

2: 94 percent / potassium carbonate / dimethylformamide / 80 °C

3: 88 percent / sodium hydroxide / dioxane; methanol; H₂O

4: thionyl chloride / ethyl acetate / 1.5 h / 80 °C

5: triethylamine / toluene / 3 h / 125 °C

6: 170 mg / 1,2-dichloro-benzene / 3.5 h / 200 °C

With pyridine; sodium hydroxide; thionyl chloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene; toluene; 5: Wittig reaction;
DOI:10.1016/j.bmc.2006.06.067