Nandrolone

Base Information

• Chemical Name: Nandrolone
• CAS No.: 434-22-0
• Deprecated CAS: 30598-74-4,409336-73-8
• Molecular Formula: C18H26O2
• Molecular Weight: 274.403
• Hs Code.: 29372900
• European Community (EC) Number: 207-101-0
• UNII: 6PG9VR430D
• DSSTox Substance ID: DTXSID7023350
• Nikkaji Number: J5.731B
• Wikipedia: Nandrolone
• Wikidata: Q421709
• NCI Thesaurus Code: C29279
• Pharos Ligand ID: M36M7GLZQ9HC
• Metabolomics Workbench ID: 35302
• ChEMBL ID: CHEMBL757
• Mol file: 434-22-0.mol

Synonyms:17-Hydroxy-Estr-4-Ene-3-One;17beta Hydroxy 19 Nor 4 Androsten 3 One;17beta-Hydroxy-19-Nor-4-Androsten-3-One;19-Nortestosterone;Estrenolone;Nandrolone;Norandrostenolone;Nortestosterone

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Nandrolone

Chemical Property:

• Appearance/Colour: Crystalline solid
• Vapor Pressure: 2.25E-09mmHg at 25°C
• Melting Point: 120-125 °C
• Refractive Index: 1.564
• Boiling Point: 434.5 °C at 760 mmHg
• PKA: 15.06±0.40(Predicted)
• Flash Point: 185.3 °C
• PSA: 37.30000
• Density: 1.13 g/cm³
• LogP: 3.48910
• Storage Temp.: Controlled Substance, -20°C Freezer
• Water Solubility.: 3.09g/L(25 oC)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 274.193280068
• Heavy Atom Count: 20
• Complexity: 466

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,T,F
• Statements: 20/21/22-64-40-61-60-36-11-38-19
• Safety Statements: 22-24/25-36/37/39-45-36/37-53-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@H]34
• Recent ClinicalTrials: Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders
• Recent EU Clinical Trials: Androgen metabolism and doping tests
• Uses: An anabolic steroid. Controlled substance (anabolic steroid)
• Therapeutic Function: Anabolic

Technology Process of Nandrolone

There total 37 articles about Nandrolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.86%

des-A-17β-t-butyldimethylsilyloxy-10-(3',3'-dioxyethylene butyl)estran-5-one → 19-nortestosterone (434-22-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 5h; Heating;

DOI:10.1002/jlcr.2580360806

Reference yield: 75.0%

estra-4-ene-3,17-dione (734-32-7) → 19-nortestosterone (434-22-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 ℃; for 6h;

Reference yield: 70.0%

3-methoxy-17-hydroxyestra-2,5(10)-diene (1091-93-6) → 19-nortestosterone (434-22-0)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1039/P19940002331

upstream raw materials:

3-methoxy-17-hydroxyestra-2,5⁽¹⁰⁾-diene

17β-hydroxy-estr-5(10)-en-3-one

3-methoxyestra-1,3,5(10),8(9)-tetraen-17β-ol

estra-4-ene-3,17-dione

Downstream raw materials:

17β-(3-cyclopentyl-propionyloxy)-estr-4-en-3-one

estradiol

estra-4-ene-3,17-dione

17β-acetoxy-5α-estran-3-one

Refernces

• 1、 Yazdi, Mojtaba Tabatabaei,Zanjanian, Seyedeh Maryam,Faramarzi, Mohammad Ali,Amini, Mohsen,Amani, Amir,Abdi, Khosrou. "Microbial transformation of nandrolone decanoate by acremonium strictum". . p. 473 - 476. Retrieved 2006.
• 2、 Fried, Stephen D.,Bagchi, Sayan,Boxer, Steven G.. "Extreme electric fields power catalysis in the active site of ketosteroid isomerase". . p. 1510 - 1514. Retrieved 2014.
• 3、 Tanaka, Takanori,Kawabata, Hirotoshi,Hayashi, Masahiko. "Nitrobenzene as hydrogen acceptor in Pd/C-catalyzed hydrogen transfer reaction". . p. 4989 - 4991. Retrieved 2005.
• 4、 Liu, Yuanyuan,Wang, Yu,Chen, Xi,Wu, Qiaqing,Wang, Min,Zhu, Dunming,Ma, Yanhe. "Regio- and stereoselective reduction of 17-oxosteroids to 17β-hydroxysteroids by a yeast strain Zygowilliopsis sp. WY7905". . p. 17 - 24. Retrieved 2016/12/22.