2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

Base Information

Chemical Name:2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester
CAS No.:657412-96-9
Molecular Formula:C₄₅H₆₁N₃O₁₀
Molecular Weight:803.993
Hs Code.:

Synonyms:2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

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Chemical Property of 2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

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Technology Process of 2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

There total 8 articles about 2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 15403-46-0
diethyl 2,5-diaminoterephthalate

: 657412-94-7
2,5-Bis-hexyloxy-N-(2-hexyloxycarbonyl-phenyl)-terephthalamic acid

: 657412-96-9
2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol036108b

Reference yield:

: 111-25-1
1-bromo-hexane

: 657412-96-9
2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 12 h / 90 °C

2: 96 percent / KOH / methanol; H₂O / 3 h / Heating

3: 63 percent / NaH / dimethylformamide / 2 h / 20 °C

4: SOCl₂ / 5 h / Heating

5: 0.23 g / Et₃N / CHCl₃ / 6 h / Heating

6: 75 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 12 h / 20 °C / 760 Torr

7: 56 percent / DCC; HOBt / CH₂Cl₂ / 12 h / 20 °C

With potassium hydroxide; thionyl chloride; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ol036108b

Reference yield:

: 5870-38-2
diethyl 2,5-(dihydroxy)terephthalate

: 657412-96-9
2-amino-5-[2,5-bis-hexyloxy-4-(2-hexyloxycarbonyl-phenylcarbamoyl)-benzoylamino]-terephthalic acid diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 12 h / 90 °C

2: 96 percent / KOH / methanol; H₂O / 3 h / Heating

3: 63 percent / NaH / dimethylformamide / 2 h / 20 °C

4: SOCl₂ / 5 h / Heating

5: 0.23 g / Et₃N / CHCl₃ / 6 h / Heating

6: 75 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 12 h / 20 °C / 760 Torr

7: 56 percent / DCC; HOBt / CH₂Cl₂ / 12 h / 20 °C

With potassium hydroxide; thionyl chloride; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ol036108b