bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

Base Information

Chemical Name:bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate
CAS No.:619333-01-6
Molecular Formula:C₃₁H₄₃F₂N₅O₇S
Molecular Weight:667.775
Hs Code.:

Synonyms:bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

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Chemical Property of bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

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Technology Process of bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

There total 7 articles about bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 619332-99-9
{3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetic acid

: C₁₆H₃₂N₄O₄

: 619333-01-6
bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

Guidance literature:: {3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetic acid; With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 0.25h;

C₁₆H₃₂N₄O₄; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b

Reference yield:

: 361336-80-3
methyl 2-(3-amino-2,6-difluorophenyl)acetate

: 619333-01-6
bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 61 percent / iPr₂NEt / CH₂Cl₂ / 20 h / 20 °C

2.1: 95 percent / aq. NaOH / methanol / 65 °C

3.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

3.2: 100 percent / CH₂Cl₂; dimethylformamide

With sodium hydroxide; PS-carbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 619333-01-6
bis-tert-butyl (1E)-amino({5-[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]pentyl}amino)dimethylidenecarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 91 percent / HNO₃ / methanol / 0.25 h / -10 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3.1: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

4.1: 68 percent / Fe; glacial acetic acid / 80 °C

5.1: 61 percent / iPr₂NEt / CH₂Cl₂ / 20 h / 20 °C

6.1: 95 percent / aq. NaOH / methanol / 65 °C

7.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

7.2: 100 percent / CH₂Cl₂; dimethylformamide

With pyridine; sodium hydroxide; PS-carbodiimide; oxalyl dichloride; nitric acid; iron; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b