methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

Base Information

Chemical Name:methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate
CAS No.:1224464-98-5
Molecular Formula:C₂₈H₂₃Cl₂N₅O₄
Molecular Weight:564.428
Hs Code.:

Synonyms:methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

Suppliers and Price of methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

There total 1 articles about methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 509083-73-2
4-((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro-[4.4]nonan-9-yl)benzonitrile

: 1224464-97-4
methyl 6-chloro-4-methylnicotinate

: 1224464-98-5
methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm100348u

Reference yield:

: 1224464-98-5
methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

: 76-05-1
trifluoroacetic acid

: C₂HF₃O₂*C₂₇H₂₁Cl₂N₅O₄

Guidance literature:: methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate; With lithium iodide; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 20h; Inert atmosphere;

trifluoroacetic acid; In methanol; water; Inert atmosphere;
DOI:10.1021/jm100348u