Methyl 6-chloro-4-Methylnicotinate

Base Information

• Chemical Name: Methyl 6-chloro-4-Methylnicotinate
• CAS No.: 1224464-97-4
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.60762
• Hs Code.: 2933399090
• Mol file: 1224464-97-4.mol

Synonyms:Methyl 6-chloro-4-Methylnicotinate;Methyl 6-chloro-4-Methylpyridine-3-carboxylate

Chemical Property of Methyl 6-chloro-4-Methylnicotinate

Chemical Property:

• Boiling Point: 252.3±35.0 °C(Predicted)
• PKA: -1.27±0.10(Predicted)
• PSA: 39.19000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 1.83000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-Chloro-4-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-chloro-4-Methylnicotinate

There total 2 articles about Methyl 6-chloro-4-Methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 6-chloro-4-methylpyridine-3-carboxylic acid (503555-50-8) → methyl 6-chloro-4-methylnicotinate (1224464-97-4)

Guidance literature:

6-chloro-4-methylpyridine-3-carboxylic acid; With trichlorophosphate; at 100 ℃; for 15h;

methanol; at 0 ℃;

Reference yield: 72.0%

5-methoxycarbonyl-4-methyl-2-hydroxypyridine (1224465-02-4) → methyl 6-chloro-4-methylnicotinate (1224464-97-4)

Guidance literature:

With trichlorophosphate; In toluene; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm100348u

Reference yield: 81.0%

4-((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro-[4.4]nonan-9-yl)benzonitrile (509083-73-2) + methyl 6-chloro-4-methylnicotinate (1224464-97-4) → methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate (1224464-98-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm100348u

upstream raw materials:

5-methoxycarbonyl-4-methyl-2-hydroxypyridine

methanol

6-chloro-4-methylpyridine-3-carboxylic acid

Downstream raw materials:

methyl 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinate

methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

2-[(2S)-2-(6-chloro-3-oxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

2-[(1S)-2-amino-1-(3-fluorobenzyl)ethyl]-6-(4-chloro-1-methyl-1H-pyrazol-5-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

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