7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

Base Information

Chemical Name:7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid
CAS No.:1202887-32-8
Molecular Formula:C₂₇H₂₁ClN₂O₅
Molecular Weight:488.927
Hs Code.:

Synonyms:7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

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Chemical Property of 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

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Technology Process of 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

There total 13 articles about 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1202890-21-8
methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

: 1202887-32-8
7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

Guidance literature:: methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 17h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; for 0.5h;

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 1202887-32-8
7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dirhodium tetraacetate / toluene / 1 h / 80 °C

2.1: methanol; sodium methylate / ethanol / 17 h / Reflux

2.3: pH 1

3.1: diphenyl phosphoryl azide; triethylamine / 17 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 0.5 h / 20 °C

5.2: 1 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 17 h / 20 °C

6.2: 0.5 h

With hydrogenchloride; methanol; diphenyl phosphoryl azide; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; dirhodium tetraacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1202890-20-7
tert-butyl 2-(4-chlorophenyl)cyclopropylcarbamate

: 1202887-32-8
7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 17 h / 20 °C

3.2: 0.5 h

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;