methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Base Information

Chemical Name:methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate
CAS No.:1202890-21-8
Molecular Formula:C₂₈H₂₃ClN₂O₅
Molecular Weight:502.954
Hs Code.:

Synonyms:methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

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Chemical Property of methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

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Technology Process of methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

There total 12 articles about methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 90562-30-4
2-(4-chlorophenyl)cyclopropanamine hydrochloride

: 1202889-60-8
4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid

: 1202890-21-8
methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: 4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

2-(4-chlorophenyl)cyclopropanamine hydrochloride; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 1202890-21-8
methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dirhodium tetraacetate / toluene / 1 h / 80 °C

2.1: methanol; sodium methylate / ethanol / 17 h / Reflux

2.3: pH 1

3.1: diphenyl phosphoryl azide; triethylamine / 17 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 0.5 h / 20 °C

5.2: 1 h / 20 °C

With hydrogenchloride; methanol; diphenyl phosphoryl azide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dirhodium tetraacetate; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1202890-20-7
tert-butyl 2-(4-chlorophenyl)cyclopropylcarbamate

: 1202890-21-8
methyl 7-(4-((2-(4-chlorophenyl)cyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;