rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

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Chemical Name:rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide
CAS No.:1394162-58-3
Molecular Formula:C₁₉H₂₁N₅O₂
Molecular Weight:351.408
Hs Code.:

Synonyms:rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

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Chemical Property of rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

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Technology Process of rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

There total 2 articles about rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394162-56-1
rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 1394162-58-3
rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Guidance literature:: rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1394162-31-2
N-(1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

: 1394162-58-3
rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 8 h / 80 - 90 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

With tetrabutylammomium bromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;