rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate
CAS No.:1394162-56-1
Molecular Formula:C₂₄H₂₉N₅O₄
Molecular Weight:451.525
Hs Code.:

Synonyms:rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Property of rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

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Technology Process of rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

There total 1 articles about rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181258-46-8
tert-butyl 2-(bromomethyl)pyrrolidine-1-carboxylate

: 1394162-31-2
N-(1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

: 1394162-56-1
rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 8h;

Reference yield:

: 1394162-56-1
rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 1394162-58-3
rac-N-(1-(pyrrolidin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Guidance literature:: rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1394162-56-1
rac-tert-butyl 2-((4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 1394161-84-2
rac-N-(1-((1-(4,6-dimethoxypyrimidin-2-yl)pyrrolidin-2-yl)methyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

2: caesium carbonate / acetonitrile / 0.5 h / 180 °C / Microwave

With caesium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;