4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile

Base Information

• Chemical Name: 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile
• CAS No.: 252061-68-0
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.337

Synonyms:4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile

Chemical Property of 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile

Chemical Property:

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Technology Process of 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile

There total 2 articles about 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-hydroxy-1,3,4,5-tetrahydro-2H-2-benzazepin-1-one (22246-81-7) + 4-cyanobenzyl bromide (17201-43-3) → 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile (252061-68-0)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol; N,N-dimethyl-formamide; at -5 ℃;

DOI:10.1021/jm990365y

Reference yield:

7-methoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one (3648-86-0) → 4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile (252061-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: BBr₃ / 20 °C

2: Triton B / dimethylformamide; methanol / -5 °C

With boron tribromide; N-benzyl-trimethylammonium hydroxide; In methanol; N,N-dimethyl-formamide; 1: demethylation / 2: Condensation;

DOI:10.1021/jm990365y

Reference yield:

4-(1-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxymethyl)-benzonitrile (252061-68-0) → {7-[4-(tert-butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-acetic acid tert-butyl ester (252061-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH

With sodium hydride; 1: Condensation;

DOI:10.1021/jm990365y

upstream raw materials:

7-hydroxy-1,3,4,5-tetrahydro-2H-2-benzazepin-1-one

4-cyanobenzyl bromide

7-methoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one

Downstream raw materials:

{7-[4-(tert-butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-acetic acid tert-butyl ester

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