(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

Base Information

Chemical Name:(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol
CAS No.:852244-92-9
Molecular Formula:C₃₁H₄₂O₄Si
Molecular Weight:506.758
Hs Code.:

Synonyms:(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

Suppliers and Price of (4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

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Chemical Property of (4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

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Technology Process of (4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

There total 4 articles about (4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2S,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexyloxy]-tert-butyl-diphenyl-silane

: 852244-92-9
(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

Guidance literature:: With W-2 Raney nickel; hydrogen; In ethanol; at 20 ℃; for 24h;
DOI:10.1021/ol0504291

Reference yield:

: 852244-91-8
(2S,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexan-1-ol

: 852244-92-9
(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 24 h / 20 °C

2: 0.57 g / W-2 Raney nickel; H₂ / ethanol / 24 h / 20 °C

With 1H-imidazole; W-2 Raney nickel; hydrogen; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0504291

Reference yield:

: 852244-89-4
(4R,5S)-3-((2R,3S)-6-Benzyloxy-3-hydroxy-2-methyl-hexanoyl)-4-methyl-5-phenyl-oxazolidin-2-one

: 852244-92-9
(4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: camphorsulfonic acid / CH₂Cl₂ / 24 h / 20 °C

2: 2.43 g / LiAlH₄ / tetrahydrofuran / 4 h / 0 °C

3: imidazole / dimethylformamide / 24 h / 20 °C

4: 0.57 g / W-2 Raney nickel; H₂ / ethanol / 24 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; W-2 Raney nickel; camphor-10-sulfonic acid; hydrogen; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0504291