(1R,2S)-1-methyl-1,2-cyclohexanediol

Base Information

• Chemical Name: (1R,2S)-1-methyl-1,2-cyclohexanediol
• CAS No.: 105928-96-9
• Molecular Formula: C₇H₁₄O₂
• Molecular Weight: 130.187
• Mol file: 105928-96-9.mol

Synonyms:(1R,2S)-1-methyl-1,2-cyclohexanediol

Chemical Property of (1R,2S)-1-methyl-1,2-cyclohexanediol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-1-methyl-1,2-cyclohexanediol

There total 60 articles about (1R,2S)-1-methyl-1,2-cyclohexanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methylcyclohex-1-ene (591-49-1) → (1R,2R)-1-methylcyclohexane-1,2-diol (6296-84-0,19534-08-8,52718-65-7,96455-86-6,105928-96-9,108392-44-5,119007-94-2,133964-50-8,105929-88-2)

Guidance literature:

With potassium osmate(VI) dihydrate; sodium dodecyl sulfate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In water; at 20 ℃; for 48h; optical yield given as %ee;

DOI:10.1002/adsc.200800269

Reference yield: 86.0%

(1R,2R,4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexane-1,2-diol (59121-82-3) → (1R,2R)-1-methylcyclohexane-1,2-diol (6296-84-0,19534-08-8,52718-65-7,96455-86-6,105928-96-9,108392-44-5,119007-94-2,133964-50-8,105929-88-2)

Guidance literature:

(1R,2R,4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexane-1,2-diol; With methanol; ozone;

With ferrous(II) sulfate heptahydrate; thiophenol; at -78 - 20 ℃; for 0.5h;

DOI:10.1126/science.aaw4212

Reference yield: 82.9%

1-methylcyclohex-1-ene (591-49-1) → trans-1-methylcyclohexane-1,2-diol (6296-84-0,19534-08-8,52718-65-7,96455-86-6,105928-96-9,105929-88-2,108392-44-5,119007-94-2,133964-50-8)

Guidance literature:

With dihydrogen peroxide; toluene-4-sulfonic acid; In water; at 50 ℃; for 21h; Sealed flask;

DOI:10.1002/adsc.201100187

upstream raw materials:

formic acid

1-methylcyclohex-1-ene

4α,5β-dihydroxy-4-methylcyclohexene

2-chloro-1-methylcylohexanol

Downstream raw materials:

2-Phenylbutyric acid

2-Phenyl-butyric acid (1R,2R)-2-hydroxy-2-methyl-cyclohexyl ester

6-oxoheptanoic acid

2-Phenyl-butyric acid (1S,2R)-2-hydroxy-2-methyl-cyclohexyl ester