3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

Base Information

Chemical Name:3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl
CAS No.:130296-09-2
Molecular Formula:C₃₈H₂₉N₅O₂
Molecular Weight:587.681
Hs Code.:

Synonyms:3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

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Chemical Property of 3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

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Technology Process of 3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

There total 10 articles about 3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 130277-03-1
3-<3-<2-(acetylamino)-5-benzyl-6-methoxypyridyl>>-5-<3-<2-(acetylamino)-5-methoxy-7-phenyl-1,8-naphthyridyl>>biphenyl

: 130296-09-2
3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

Guidance literature:: With hydrogen bromide; In acetic acid; for 1.5h; Heating;

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 130296-09-2
3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

Guidance literature:: Multi-step reaction with 9 steps

1: 62.4 percent / diphenyl ether / 1.) 130 deg C, 40 min, 2.) reflux, 2 h

2: 3 h / 50 - 60 °C

3: NaHCO₃ / methanol / 1.5 h

4: 36 percent / Ag₂O / acetone / 2 h / Heating

5: 91 percent / 10percent aq. NaOH / methanol / Ambient temperature

6: 61 percent / Br₂, I₂ / CH₂Cl₂ / 24 h / Ambient temperature

7: 91 percent / 1.5 h / 70 - 80 °C

8: 1.) (Ph₃P)2PdCl₂, 2.) Ac₂O / 1.) toluene, from 105 to 110 deg C, 16 h, 2.) 70 deg C, 1 h

9: 75 percent / 48percent aq. HBr, AcOH / acetic acid / 1.5 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; hydrogen bromide; bromine; iodine; acetic anhydride; sodium hydrogencarbonate; acetic acid; silver(l) oxide; In methanol; diphenylether; dichloromethane; acetic acid; acetone;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 130296-09-2
3-<5-(6-amino-3-benzyl-2-oxopyridyl)>-5-<3-(2-amino-5-oxo-7-phenyl-1,8-naphthyridinyl)>biphenyl

Guidance literature:: Multi-step reaction with 9 steps

1: 62.4 percent / diphenyl ether / 1.) 130 deg C, 40 min, 2.) reflux, 2 h

2: 3 h / 50 - 60 °C

3: NaHCO₃ / methanol / 1.5 h

4: 36 percent / Ag₂O / acetone / 2 h / Heating

5: 91 percent / 10percent aq. NaOH / methanol / Ambient temperature

6: 61 percent / Br₂, I₂ / CH₂Cl₂ / 24 h / Ambient temperature

7: 91 percent / 1.5 h / 70 - 80 °C

8: 1.) (Ph₃P)2PdCl₂, 2.) Ac₂O / 1.) toluene, from 105 to 110 deg C, 16 h, 2.) 70 deg C, 1 h

9: 75 percent / 48percent aq. HBr, AcOH / acetic acid / 1.5 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; hydrogen bromide; bromine; iodine; acetic anhydride; sodium hydrogencarbonate; acetic acid; silver(l) oxide; In methanol; diphenylether; dichloromethane; acetic acid; acetone;