methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate

Base Information

• Chemical Name: methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate
• CAS No.: 894774-82-4
• Molecular Formula: C₁₃H₁₄ClNO₃S
• Molecular Weight: 299.778
• Mol file: 894774-82-4.mol

Synonyms:methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate

Chemical Property of methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate

There total 1 articles about methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (4R)-2-phenylthiazolidine-4-carboxylate (198991-76-3,69739-20-4) + chloroacetyl chloride (79-04-9) → methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate (894774-82-4)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.3987/COM-05-10662

Reference yield: 100.0%

methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate (894774-82-4) → methyl (2R,4R)-N-iodoacetyl-2-phenylthiazolidine-4-carboxylate (894774-83-5)

Guidance literature:

With sodium iodide; In acetone; at 20 ℃; for 12h;

DOI:10.3987/COM-05-10662

Reference yield:

methyl (2R,4R)-N-chloroacetyl-2-phenylthiazolidine-4-carboxylate (894774-82-4) → (3R,8aR)-7-[(1R)-2-phenyl-1-methoxycarbonylethyl]-3-phenyltetrahydrothiazolo[3,4-a]pyrazine-5,8-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / NaI / acetone / 12 h / 20 °C

2: 64 percent / NaHCO₃ / toluene / 40 h / Heating

With sodium hydrogencarbonate; sodium iodide; In acetone; toluene;

DOI:10.3987/COM-05-10662

upstream raw materials:

methyl (4R)-2-phenylthiazolidine-4-carboxylate

chloroacetyl chloride

Downstream raw materials:

methyl (2R,4R)-N-iodoacetyl-2-phenylthiazolidine-4-carboxylate