ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

Base Information

Chemical Name:ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate
CAS No.:470456-28-1
Molecular Formula:C₂₄H₂₁N₅O₄S
Molecular Weight:475.528
Hs Code.:

Synonyms:ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

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Chemical Property of ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

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Technology Process of ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

There total 6 articles about ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 105-53-3
diethyl malonate

: 470456-12-3
1-[4-Hydrazino-9-(4-methoxy-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

: 470456-28-1
ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

Guidance literature:: for 2h; Heating;
DOI:10.1002/jccs.200200035

Reference yield:

: 121104-38-9
5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridine-2(1H)-thione

: 470456-28-1
ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / CH₃CO₂Na*3H₂O / ethanol / 2 h / Heating

2: 91 percent / NaOEt / ethanol / 0.33 h / Heating

3: 85 percent / Ac₂O / 3 h / Heating

4: 86 percent / POCl₃ / 4 h / Heating

5: 93 percent / hydrazine hydrate / ethanol / 2 h / Heating

6: 78 percent / 2 h / Heating

With sodium ethanolate; sodium acetate; acetic anhydride; hydrazine hydrate; trichlorophosphate; In ethanol;
DOI:10.1002/jccs.200200035

Reference yield:

: 470455-86-8
2-[5-acetyl-3-cyano-4-(4-methoxy-phenyl)-6-methyl-pyridin-2-ylsulfanyl]-acetamide

: 470456-28-1
ethyl (8-acetyl-7-(4'-methoxyphenyl)-9-methyl-s-triazolo[4'',3''-c]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / NaOEt / ethanol / 0.33 h / Heating

2: 85 percent / Ac₂O / 3 h / Heating

3: 86 percent / POCl₃ / 4 h / Heating

4: 93 percent / hydrazine hydrate / ethanol / 2 h / Heating

5: 78 percent / 2 h / Heating

With sodium ethanolate; acetic anhydride; hydrazine hydrate; trichlorophosphate; In ethanol;
DOI:10.1002/jccs.200200035