2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

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Chemical Name:2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile
CAS No.:1373522-51-0
Molecular Formula:C₂₄H₃₂BN₃O₄
Molecular Weight:437.347
Hs Code.:

Synonyms:2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

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Chemical Property of 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

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Technology Process of 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

There total 4 articles about 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1373522-50-9
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

: 1373522-51-0
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile; With Triisopropyl borate; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 1.08333h;

With 2,3-dimethyl-2,3-butane diol; acetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm2016107

Reference yield:

: 1373522-52-1
C₁₈H₂₁N₃O₂

: 1373522-51-0
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol / 1 h / 20 °C

2.1: trifluoroacetic acid / toluene / 2 h / 80 °C

3.1: Triisopropyl borate; lithium diisopropyl amide / tetrahydrofuran / 1.08 h / -78 - 20 °C

3.2: 20 °C

With hydrogenchloride; Triisopropyl borate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm2016107

Reference yield:

: C₁₃H₁₃N₃O

: 1373522-51-0
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / toluene / 2 h / 80 °C

2.1: Triisopropyl borate; lithium diisopropyl amide / tetrahydrofuran / 1.08 h / -78 - 20 °C

2.2: 20 °C

With Triisopropyl borate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/jm2016107