2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

Base Information

Chemical Name:2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile
CAS No.:1373522-50-9
Molecular Formula:C₁₈H₂₁N₃O₂
Molecular Weight:311.384
Hs Code.:

Synonyms:2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

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Chemical Property of 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

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Technology Process of 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

There total 3 articles about 2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: C₁₃H₁₃N₃O

: 1373522-50-9
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: With trifluoroacetic acid; In toluene; at 80 ℃; for 2h;
DOI:10.1021/jm2016107

Reference yield:

: 1373522-52-1
C₁₈H₂₁N₃O₂

: 1373522-50-9
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 1 h / 20 °C

2: trifluoroacetic acid / toluene / 2 h / 80 °C

With hydrogenchloride; trifluoroacetic acid; In methanol; toluene;
DOI:10.1021/jm2016107

Reference yield:

: 515832-52-7
5-bromo-2-[(1-methylethyl)oxy]benzonitrile

: 1373522-50-9
2-isopropoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

2: hydrogenchloride / methanol / 1 h / 20 °C

3: trifluoroacetic acid / toluene / 2 h / 80 °C

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluoroacetic acid; tricyclohexylphosphine; In 1,4-dioxane; methanol; toluene;
DOI:10.1021/jm2016107