11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one

Base Information

• Chemical Name: 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one
• CAS No.: 192212-95-6
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472

Synonyms:11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one

Chemical Property of 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one

Chemical Property:

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Technology Process of 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one

There total 6 articles about 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-12,13-dione (192212-94-5) → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-12-one (192212-95-6)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; for 5h; Heating;

DOI:10.1021/jo9700787

Reference yield:

1-carbomethoxy-6-methoxy-2-tetralone (13838-42-1) → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-12-one (192212-95-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 65 percent / K₂CO₃ / acetone / 3 h / Heating

2: 16 percent / acetic acid; H₂O / 3 h / Heating

3: dioxane / 4 h / Ambient temperature

4: DBU / toluene / Heating

5: 71 percent / hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 5 h / Heating

With potassium hydroxide; potassium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; water; acetic acid; acetone; toluene; diethylene glycol;

DOI:10.1021/jo9700787

Reference yield:

6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester (151533-44-7) → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-12-one (192212-95-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 16 percent / acetic acid; H₂O / 3 h / Heating

2: dioxane / 4 h / Ambient temperature

3: DBU / toluene / Heating

4: 71 percent / hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 5 h / Heating

With potassium hydroxide; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; water; acetic acid; toluene; diethylene glycol;

DOI:10.1021/jo9700787

upstream raw materials:

11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione

2,4-Dimethoxybenzylamine

1-carbomethoxy-6-methoxy-2-tetralone

6-Methoxy-1-methyl-3-methylene-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

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