4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

Base Information

Chemical Name:4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate
CAS No.:1472067-91-6
Molecular Formula:C₁₇H₁₄F₂N₆O₃S
Molecular Weight:420.399
Hs Code.:

Synonyms:4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

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Chemical Property of 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

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Technology Process of 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

There total 7 articles about 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1472068-33-9
4-({[3-(difluoromethyl)-4-{[tris(propan-2-yl)silyl]oxy}phenyl]methyl}(4H-1,2,4-triazol-4-yl)amino)benzonitrile

: 1472067-91-6
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 24589-99-9
methyl 3-formyl-4-hydroxybenzoate

: 1472067-91-6
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 7 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; ethanol / 6 h

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: Trimethyl borate; lithium borohydride / diethyl ether

4: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

5: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 20 °C

7: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With 1H-imidazole; lithium borohydride; Trimethyl borate; sulphamoyl chloride; tetrabutyl ammonium fluoride; phosphorus tribromide; sodium hydride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1472068-30-6
(3-difluoromethyl-4-triisopropylsilanyloxyphenyl)methanol

: 1472067-91-6
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-2-(difluoromethyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 20 °C

4: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With sulphamoyl chloride; tetrabutyl ammonium fluoride; phosphorus tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015