24589-99-9

Basic information

• Product Name: METHYL 3-FORMYL-4-HYDROXYBENZOATE
• Synonyms: 3-formyl-4-hydroxy-benzoicacimethylester;4-hydroxyisophthalaldehydeacidmethylester;4-hydroxy-isophthalaldehydicacimethylester;5-carbomethoxysalicylaldehyde;METHYL 3-FORMYL-4-HYDROXYBENZOATE;5-(METHOXYCARBONYL)SALICYLALDEHYDE;3-Formyl-4-hydroxybenzoesä:ure-methylester, 5-(Methoxycarbonyl)salicylaldehyde;Benzoic acid, 3-forMyl-4-hydroxy-, Methyl ester
• CAS NO: 24589-99-9
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• EINECS: 1533716-785-6
• Mol File: 24589-99-9.mol
• Article Data: 44

Chemical Properties

• Melting Point: 80-84 °C
• Boiling Point: 299.287 °C at 760 mmHg
• Flash Point: 120.527 °C
• Appearance: /
• Density: 1.311 g/cm³
• Vapor Pressure: 0.000677mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.56±0.18(Predicted)
• CAS DataBase Reference: METHYL 3-FORMYL-4-HYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-FORMYL-4-HYDROXYBENZOATE(24589-99-9)
• EPA Substance Registry System: METHYL 3-FORMYL-4-HYDROXYBENZOATE(24589-99-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: DH1421520
• Hazardous Substances Data: 24589-99-9(Hazardous Substances Data)

Usage

Uses

Methyl 3-Formyl-4-hydroxybenzoate is a useful synthetic intermediate in the synthesis of 1,2-Benzisoxazole-5-carboxylic Acid (B197900). Also a useful synthetic intermediate in the synthesis of Roflumilast (R639700); a selective phosphodiesterase 4 (PDE4) inhibitor and antiasthmatic in the treatment of chronic obstructive pulmonary disease.

InChI:InChI=1/C9H8O4/c1-13-9(12)6-2-3-8(11)7(4-6)5-10/h2-5,11H,1H3

Upstream product

• 100-97-0 hexamethylenetetramine 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 50-00-0 formaldehyd 
• 52178-50-4 Methyl 3-formylbenzoate 
• 59648-31-6 4-hydroxy-3-hydroxymethylbenzoic acid methyl ester 
• 140-88-5 ethyl acrylate 
• 584-87-2 3-formyl-4-hydroxybenzoic acid 
• 76-05-1 trifluoroacetic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 108-43-0 3-monochlorophenol 
• 67-56-1 methanol 

Downstream Products

• 90334-73-9 4-Hydroxy-3-[(E)-phenyliminomethyl]-benzoic acid methyl ester 
• 163163-68-6 methyl 3-formyl-4-<(2-chloroethyl)oxy>benzoate 
• 706820-79-3 methyl 3-bromo-5-formyl-4-hydroxybenzoate 
• 882810-08-4 4-hydroxy-3-(1-hydroxy-3-methylbut-2-enyl)benzoic acid methyl ester 
• 882810-12-0 4-hydroxy-3-(1-hydroxybut-2-enyl)benzoic acid methyl ester 
• 252234-27-8 4-carbomethoxy-2-[4-benzyloxy-E-1-butenyl]phenol 
• 947232-28-2 methyl 4-(tert-butyldimethylsilyloxy)-3-formyl-benzoate 
• 156001-68-2 methyl 3-cyano-4-hydroxybenzoate 
• 145742-55-8 methyl 3-formyl-4-methoxybenzoate 
• 1193731-89-3 (E)-methyl 3-((2-acetylhydrazono)methyl)-4-methylhydroxybezoate 
• 1224447-24-8 C₁₈H₁₄O₈ 
• 1289164-47-1 4-(cyclopropylmethoxy)-3-formylbenzoic acid 
• 1428847-87-3 2-(benzyloxy)-2-oxoethyl 4-(cyclopropylmethoxy)-3-formylbenzoate 
• 1428847-88-4 2-(benzyloxy)-2-oxoethyl 4-(cyclopropylmethoxy)-3-(morpholinomethyl)benzoate? 

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