methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride

Base Information

• Chemical Name: methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride
• CAS No.: 913652-22-9
• Molecular Formula: C₁₉H₁₇ClN₂O₂S*ClH
• Molecular Weight: 409.336
• Mol file: 913652-22-9.mol

Synonyms:methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride

Chemical Property of methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride

There total 9 articles about methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carbonitrile (913652-12-7) → methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride (913652-22-9)

Guidance literature:

methanol; 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carbonitrile; With sodium hydride; at 20 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield:

5-chloro-2-hydroxyacetophenone (1450-74-4) → methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride (913652-22-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium carbonate / 2 h / Heating / reflux

2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux

3.1: water / ethanol / 1.5 h / 90 °C

4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

6.2: 0.02 h

6.3: 1.5 h / 0 - 20 °C

7.1: sodium hydroxide; water / ethanol / 20 - 60 °C

8.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

9.1: phosphorus (III) oxychloride / 1 h / 90 °C

10.1: sodium hydride / 20 °C

With Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; phosphorus (III) oxychloride; water; iodine; sodium hydride; potassium carbonate; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxylic acid (913651-21-5) → methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride (913652-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

2: phosphorus (III) oxychloride / 1 h / 90 °C

3: sodium hydride / 20 °C

With 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; phosphorus (III) oxychloride; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

upstream raw materials:

methanol

2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carbonitrile

2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxamide

2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxylic acid

Downstream raw materials:

2-(2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-3H-benzimidazol-5-yl)ethanol

2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride