N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

Base Information

• Chemical Name: N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride
• CAS No.: 343337-74-6
• Molecular Formula: C₈H₄ClF₄NO₂S
• Molecular Weight: 289.638
• Mol file: 343337-74-6.mol

Synonyms:N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

Chemical Property of N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

There total 2 articles about N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-fluoro-N-((trifluoromethyl)sulfonyl)benzamide (39063-00-8) → N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride (343337-74-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 2h; Heating;

DOI:10.1002/1099-0690(200104)2001:7<1225::AID-EJOC1225>3.0.CO;2-6

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride (343337-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / triethylamine / diethyl ether / 2 h / Heating

2: 95 percent / PCl₅; POCl₃ / 2 h / Heating

With phosphorus pentachloride; triethylamine; trichlorophosphate; In diethyl ether;

DOI:10.1002/1099-0690(200104)2001:7<1225::AID-EJOC1225>3.0.CO;2-6

Reference yield: 86.0%

N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride (343337-74-6) → N'-trifluoromethylsulfonyl-4-fluorobenzamidine (1123923-51-2,1124228-21-2)

Guidance literature:

With ammonia; In diethyl ether; at -15 ℃; for 0.333333h;

DOI:10.1016/j.jfluchem.2008.03.001

upstream raw materials:

4-fluoro-N-((trifluoromethyl)sulfonyl)benzamide

4-fluorobenzoyl chloride

Downstream raw materials:

C,C,C-trifluoro-N-[(4-fluoro-phenylimino)-methylene]-methanesulfonamide

N'-trifluoromethylsulfonyl-4-fluorobenzamidine

1-trifluoromethylsulfonylamino-2-(4-fluorophenyl)-2,3-dimorpholine-4-yl-propane

2-trifluoromethylsulfonylamino-2-(4-fluorobenzyl)-1,3-dimorpholine-4-yl-propane