N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane
• CAS No.: 173414-80-7
• Molecular Formula: C₂₃H₃₂N₄O₅
• Molecular Weight: 444.531
• Mol file: 173414-80-7.mol

Synonyms:N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane

Chemical Property of N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane

There total 1 articles about N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-BOC-1,2-diaminoethane (57260-73-8) + 1-(Benzyloxy)-3-(carboxyethyl)-5,6-dimethyl-2(1H)-pyrazinone (162610-61-9) → N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane (173414-80-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/0040-4020(95)00839-Z

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane (173414-80-7) + trifluoroacetic acid (76-05-1) → N-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane trifluoroacetate

Guidance literature:

In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4020(95)00839-Z

Reference yield:

N-(tert-butoxycarbonyl)-N'-3-(1-benzyloxy-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl)propanoyldiaminoethane (173414-80-7) → 1,1,1-tris<2-<2-<3-<1-(benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanamide>ethylaminocarbonyl>ethyloxymethyl>ethane (173414-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 0.5 h / 0 °C

2: 51 percent / NEt₃ / dimethylformamide / 48 h / 38 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(95)00839-Z

upstream raw materials:

N-BOC-1,2-diaminoethane

1-(Benzyloxy)-3-(carboxyethyl)-5,6-dimethyl-2(1H)-pyrazinone

Downstream raw materials:

1,1,1-tris<2-<2-<3-<1-(benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanamide>ethylaminocarbonyl>ethyloxymethyl>ethane