2,3-epoxy-3-cyclohexylpropionic acid

Base Information

• Chemical Name: 2,3-epoxy-3-cyclohexylpropionic acid
• CAS No.: 4442-91-5
• Molecular Formula: C₉H₁₄O₃
• Molecular Weight: 170.208
• Mol file: 4442-91-5.mol

Synonyms:2,3-epoxy-3-cyclohexylpropionic acid

Chemical Property of 2,3-epoxy-3-cyclohexylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-epoxy-3-cyclohexylpropionic acid

There total 3 articles about 2,3-epoxy-3-cyclohexylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyclohexylacrylic acid (4484-35-9) → 2,3-epoxy-3-cyclohexylpropionic acid (4442-91-5)

Guidance literature:

3-cyclohexylacrylic acid; With sodium hydroxide; dihydrogen peroxide; sodium tungstate; In methanol; water; at 40 ℃; for 20h; pH=4.5 - 6.0;

With hydrogenchloride; In tert-butyl methyl ether; water; for 1h; pH=2.0 - 3.0;

Reference yield:

(1S,3S,4R)-2-carboxymethyl-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane hexafluorophosphate + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2,3-epoxy-3-cyclohexylpropionic acid (4442-91-5)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -50 ℃;

DOI:10.1039/b418740g

Reference yield:

1-carboxymethyl-tetrahydro-thiophenium bromide + cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-oxirane carboxylic acid (4442-91-5,95979-08-1,101972-47-8)

Guidance literature:

1-carboxymethyl-tetrahydro-thiophenium bromide; With dimsylsodium; In dimethyl sulfoxide; for 0.5h;

cyclohexanecarbaldehyde; In dimethyl sulfoxide; at 20 ℃; for 18h;

DOI:10.1039/b418740g

upstream raw materials:

cyclohexanecarbaldehyde

cyclohexanone

3-cyclohexylacrylic acid

Downstream raw materials:

(2S,3S)-3-Cyclohexyl-2-hydroxy-butyric acid

anti-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid

2-benzylamino-3-cyclohexyl-3-hydroxypropionic acid

(2S,3S)-2-Acetoxy-3-cyclohexyl-butyric acid methyl ester