syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid

Base Information

• Chemical Name: syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid
• CAS No.: 101972-51-4
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.251
• Mol file: 101972-51-4.mol

Synonyms:syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid

Chemical Property of syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid

There total 4 articles about syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propionic acid (802294-64-0,79-09-4) + cyclohexanecarbaldehyde (2043-61-0) → anti-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid (101972-51-4,131897-90-0,131897-91-1,138603-03-9) + syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid (101972-51-4)

Guidance literature:

propionic acid; With B-bromodicyclohexylborane; triethylamine; In diethyl ether; at 0 ℃; for 0.75h; Inert atmosphere;

cyclohexanecarbaldehyde; In diethyl ether; at -78 - 0 ℃; for 1.5h; Overall yield = 82 %; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.048

Reference yield:

propionic acid (802294-64-0,79-09-4) + cyclohexanecarbaldehyde (2043-61-0) → anti-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid (101972-51-4,131897-90-0,131897-91-1,138603-03-9) + syn-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid (101972-51-4)

Guidance literature:

propionic acid; With B-bromodicyclohexylborane; triethylamine; In diethyl ether; at 0 ℃; for 0.75h; Inert atmosphere;

cyclohexanecarbaldehyde; In diethyl ether; at -78 - 0 ℃; for 1.5h; Overall yield = 82 %; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.048

Reference yield:

3-cyclohexyl-oxirane carboxylic acid (4442-91-5,95979-08-1,101972-47-8) → (2S,3S)-3-Cyclohexyl-2-hydroxy-butyric acid (101972-56-9) + anti-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid (101972-51-4,131897-90-0,131897-91-1,138603-03-9)

Guidance literature:

In diethyl ether; at 0 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)94923-2

upstream raw materials:

3-cyclohexyl-oxirane carboxylic acid

propionic acid

cyclohexanecarbaldehyde

Downstream raw materials:

trans-(+/-)-4-cyclohexyl-3-methyloxetan-2-one