7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

Base Information

Chemical Name:7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile
CAS No.:1616489-99-6
Molecular Formula:C₂₁H₁₆F₃N₃O₃
Molecular Weight:415.372
Hs Code.:

Synonyms:7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

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Chemical Property of 7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

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Technology Process of 7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

There total 3 articles about 7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 784-57-6
2-(morpholin-4-yl)-5-(trifluoromethyl)aniline

: 1616489-94-1
2-oxo-7-(trifluoromethanesulfonyloxy)-2Hchromene-6-carbonitrile

: 1616489-99-6
7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In N,N-dimethyl-formamide; at 135 - 140 ℃; for 16h; Inert atmosphere;
DOI:10.1134/S107042801405008X

Reference yield:

: 92200-28-7
oreoselone oxime

: 1616489-99-6
7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentachloride

2: pyridine / 48 h / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / N,N-dimethyl-formamide / 16 h / 135 - 140 °C / Inert atmosphere

With pyridine; phosphorus pentachloride; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In N,N-dimethyl-formamide; 1: |Beckmann Rearrangement;
DOI:10.1134/S107042801405008X

Reference yield:

: 7-hydroxy-2-oxo-2H-1-benzopyran-6-carbonitrile

: 1616489-99-6
7-{[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-amino}-2-oxo-2H-chromene-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 48 h / 0 - 20 °C / Inert atmosphere

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / N,N-dimethyl-formamide / 16 h / 135 - 140 °C / Inert atmosphere

With pyridine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1134/S107042801405008X