methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate

Base Information

• Chemical Name: methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate
• CAS No.: 1190618-39-3
• Molecular Formula: C₂₆H₂₆ClN₅O₃S
• Molecular Weight: 524.043
• Mol file: 1190618-39-3.mol

Synonyms:methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate

Chemical Property of methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate

There total 5 articles about methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-chloro-benzothiazol-2-yl)-[4-(2-hydrazino-pyridin-4-yl)-phenyl]-amine (1190618-33-7) + (R)-3-(methoxycarbonyl)-4-methylpentanoic acid (220498-08-8) → methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate (1190618-39-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

N-(4-bromophenyl)-6-chlorobenzo[d]thiazol-2-amine → methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate (1190618-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

3: pyridine; hydrazine / 20 h / 75 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

4-bromo-aniline (106-40-1) → methyl (R)-4-(2-(4-(4-(6-chloro-benzo[d]thiazol-2-ylamino)phenyl)pyridin-2-yl)hydrazino)-2-isopropyl-4-oxo-butanoate (1190618-39-3)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 140 °C / Microwave irradiation

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

4: pyridine; hydrazine / 20 h / 75 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; hydrogenchloride; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

(6-chloro-benzothiazol-2-yl)-[4-(2-hydrazino-pyridin-4-yl)-phenyl]-amine

(R)-3-(methoxycarbonyl)-4-methylpentanoic acid

2,6-dichloro-1,3-benzothiazole

6-chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]thiazol-2-amine