Technology Process of (3aR,4R,5S,6S,7R,7aS)-4,5,6-Tris-benzyloxy-7-(1-ethoxy-ethoxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxole
There total 7 articles about (3aR,4R,5S,6S,7R,7aS)-4,5,6-Tris-benzyloxy-7-(1-ethoxy-ethoxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaOAc, Baker's yeast / H2O / 7 h / 45 °C
2: DMAP, DIPEA / CH2Cl2 / 48 h / Ambient temperature
3: 48 percent / formic acid, sodium formate, NaOH / H2O / 31 h / Heating
4: 90 percent / PhSO3H / acetonitrile; tetrahydrofuran / 2 h
5: 97 percent / AcOH / dimethylformamide / 2 h / Ambient temperature
6: 100 percent / EtONa / methanol / 5 h / Heating
7: 46 percent / NaH / dimethylformamide / 4 h / Ambient temperature
With
dmap; sodium hydroxide; formic acid; baker's yeast; sodium ethanolate; sodium formate; sodium acetate; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; benzenesulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0008-6215(97)00131-6
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / PhSO3H / acetonitrile; tetrahydrofuran / 2 h
2: 97 percent / AcOH / dimethylformamide / 2 h / Ambient temperature
3: 100 percent / EtONa / methanol / 5 h / Heating
4: 46 percent / NaH / dimethylformamide / 4 h / Ambient temperature
With
sodium ethanolate; sodium hydride; acetic acid; benzenesulfonic acid;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0008-6215(97)00131-6
