2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

Base Information

Chemical Name:2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester
CAS No.:740836-16-2
Molecular Formula:C₆₀H₈₇NO₁₀Si₂
Molecular Weight:1038.52
Hs Code.:

2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

Synonyms:2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

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Chemical Property of 2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

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Technology Process of 2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

There total 5 articles about 2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: (2R)-2,3-dimethoxypropanoic acid

: 740836-31-1
Acetic acid (1R,2S,3R,6S,7S,9S,10R)-9,11-bis-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(R)-3-(formyl-methyl-amino)-1-methyl-allyl]-3-hydroxy-7-methoxy-2,6,10-trimethyl-undecyl ester

: 740836-16-2
2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

Guidance literature:: With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/j.tet.2006.06.046

Reference yield:

: 909803-76-5
Acetic acid (1R,2S,3R,6S,7S,9S,10R)-9,11-bis-(tert-butyl-diphenyl-silanyloxy)-3-(3,4-dimethoxy-benzyloxymethoxy)-7-methoxy-2,6,10-trimethyl-1-((R)-1-methyl-3-oxo-propyl)-undecyl ester

: 740836-16-2
2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / hydroquinone; pyridinium p-toluenesulfonate; molecular sieves 3 Angstroem / benzene / 5 h / Heating

2: 90 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone; phosphate buffer / CH₂Cl₂; 2-methyl-propan-2-ol / 0 - 20 °C

3: 74 percent / triethylamine; 2,4,6-trichlorobenzoyl chloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h / 20 °C

With dmap; phosphate buffer; 3 A molecular sieve; 2,4,6-trichlorobenzoyl chloride; pyridinium p-toluenesulfonate; triethylamine; hydroquinone; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1016/j.tet.2006.06.046

Reference yield:

: 740836-14-0
Acetic acid (1R,2S,3R,6S,7S,9S,10R)-9,11-bis-(tert-butyl-diphenyl-silanyloxy)-3-(3,4-dimethoxy-benzyloxymethoxy)-1-((R)-3-hydroxy-1-methyl-propyl)-7-methoxy-2,6,10-trimethyl-undecyl ester

: 740836-16-2
2,3-Dimethoxy-propionic acid (1R,4S,5S,7S,8R)-1-[(E)-(1S,2R,3R)-2-acetoxy-5-(formyl-methyl-amino)-1,3-dimethyl-pent-4-enyl]-7,9-bis-(tert-butyl-diphenyl-silanyloxy)-5-methoxy-4,8-dimethyl-nonyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

2: 55 percent / hydroquinone; pyridinium p-toluenesulfonate; molecular sieves 3 Angstroem / benzene / 5 h / Heating

3: 90 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone; phosphate buffer / CH₂Cl₂; 2-methyl-propan-2-ol / 0 - 20 °C

4: 74 percent / triethylamine; 2,4,6-trichlorobenzoyl chloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h / 20 °C

With dmap; phosphate buffer; 3 A molecular sieve; 2,4,6-trichlorobenzoyl chloride; pyridinium p-toluenesulfonate; Dess-Martin periodane; triethylamine; hydroquinone; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1016/j.tet.2006.06.046